Approximate Dynamic Programming and Its Applications to the Design of Phase I Cancer Trials
نویسندگان
چکیده
منابع مشابه
Approximate Dynamic Programming and Its Applications to the Design of Phase I Cancer Trials
Optimal design of a Phase I cancer trial can be formulated as a stochastic optimization problem. By making use of recent advances in approximate dynamic programming to tackle the problem, we develop an approximation of the Bayesian optimal design. The resulting design is a convex combination of a “treatment” design, such as Babb et al.’s (1998) escalation with overdose control, and a “learning”...
متن کاملApproximate Dynamic Programming I: Modeling
Stochastic optimization problems pose unique challenges in how they are represented mathematically. These problems arise in a number of different communities, often in the context of problems that introduce specific computational characteristics. As a result, a number of contrasting notational styles have evolved, which complicate our ability to communicate research across communities. This is ...
متن کاملThe continual reassessment method and its applications: a Bayesian methodology for phase I cancer clinical trials.
We discuss the continual reassessment method (CRM) and its extension with practical applications in phase I and I/II cancer clinical trials. The CRM has been proposed as an alternative design of a traditional cohort design and its essential features are the sequential (continual) selection of a dose level for the next patients based on the dose-toxicity relationship and the updating of the rela...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولModern Computational Applications of Dynamic Programming
Computational dynamic programming, while of some use for situations typically encountered in industrial and systems engineering, has proved to be of much greater significance in many areas of computer science. We review some of these applications here.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistical Science
سال: 2010
ISSN: 0883-4237
DOI: 10.1214/10-sts317